BREAKING NEWS

India drops Plasma Therapy for COVID treatment

Plasma therapy on COVID-19 patients has not been found effective in reducing the progression to severe disease or death and is dropped from the clinical management guidelines, the Indian Council of Medical Research (ICMR) stated.
 
An Indian Council of Medical Research (ICMR) official said the task force “revised” the Clinical Guidance for Management of Adult COVID-19 Patients and “dropped convalescent plasma (off label)”.
 
With the cases surging in the country, there has been a spur in the demand for plasma donors, even as experts raise concerns over the efficacy of plasma therapy for Covid-19 patients.
 
Earlier in a meeting of the ICMR-National Task Force for COVID-19 on Friday, all members were in favour of removing the use of convalescent plasma from the Clinical Guidance for Management of Adult COVID-19 Patients citing its ineffectiveness and inappropriate use in several cases, as per reports.
 
The present guidelines allows "off label" use of plasma therapy at the stage of early moderate disease, that is, within seven days of the onset of symptoms and if there is availability of a high titre donor plasma.
 
The decision to remove it from the guidelines comes in the backdrop of some clinicians and scientists writing to Principal Scientific Advisor K. VijayRaghavan cautioning against the “irrational and non-scientific use” of convalescent plasma for COVID-19 in the country.
 
In the letter, which was also marked to ICMR chief Balram Bhargava and AIIMS Director Randeep Guleria, public health professionals alleged that the current guidelines on plasma therapy are not based on existing evidence and pointed out some very early evidence that indicates a possible association between emergence of variants with “lower susceptibility to neutralising antibodies in immunosuppressed” people given plasma therapy.
 
This raises the possibility of more virulent strains developing due to irrational use of plasma therapy which can fuel the pandemic, according to the letter signed by vaccinologist Gagandeep Kang, surgeon Pramesh C.S. and others. 

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